{"product_id":"new-product-233083","title":"ADAMTS2 polyclonal antibody","description":"\u003cp\u003eADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a C-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver. ADAMTS-2 cleaves the propeptides of Collagen Type I and II, but not Collagen Type III, prior to fibril assembly. It may also play a role in development aside from collagen biosynthesis. ADAMTS-2 is secreted and associated with the extracellular matrix, with the highest levels in skin, bone, tendon and aorta. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type VIIC (EDS VIIC), a recessively inherited connective-tissue disorder characterized clinically by severe skin fragility and joint hypermobility.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47664144023832,"sku":"BS60092","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_140a151e-1543-405c-b46a-49de420263f4.jpg?v=1707510676","url":"https:\/\/danabiosci.com\/products\/new-product-233083","provider":"Dana Bioscience","version":"1.0","type":"link"}