{"product_id":"new-product-232919","title":"HIPK2 polyclonal antibody","description":"\u003cp\u003eThe Homeodomain-Interacting Protein Kinase (HIPK) family, which includes HIPK1, HIPK2, HIPK3, contains a conserved protein kinase domain as well as a separate domain that interacts with homeoproteins. HIPK2, the most highly characterized family member, is thought to act as a co-repressor of homeodomain transcription factors as HIPK2 has been shown to enhance the DNA binding of the NK-3 homeoprotein in vitro. It is regulated by a posttranslational modification of a ubiquitin-like protein, SUMO-1, via covalent bonding to a lysine residue on HIPK2. This is similar to the binding of SUMO-1 to PML and Sp100. The conjugation of SUMO-1 is thought to direct each of these proteins to nuclear bodies (NBs), which appear to play a role in autoimmunity and viral protection. HIPK2 is the first protein kinase to be directed to nuclear bodies in response to ubiquitin-like modification.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47664101261592,"sku":"BS60320","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_c1820810-d0a9-46b1-b31a-8eea16f2c5c6.jpg?v=1707509993","url":"https:\/\/danabiosci.com\/products\/new-product-232919","provider":"Dana Bioscience","version":"1.0","type":"link"}