{"product_id":"new-product-232913","title":"IL-27Rα polyclonal antibody","description":"\u003cp\u003eIL-27 is a heterodimeric cytokine that consists of EBI3, an IL-12p40-related protein, and p28, a IL-12p35-related polypeptide. IL-27 triggers expansion of antigen-specific naive CD4-positive T cells and promotes polarization towards a Th1 phenotype with expression of gamma-interferon. IL-27 contributes to the development of an adaptive immune response through its action on CD4-positive T cells, and also directly acts on cells of the innate immune system. IL-27 protein levels increase upon activation of antigen-presenting cells. IL-27 protein induces orphan cytokine receptor IL-27R (WSX-1)-dependent clonal expansion of naive but not memory CD4(+) T cells. IL-27 signaling through IL-27R and gp130 also induces phosphorylation of Stat1-5.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47664098378008,"sku":"BS60331","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_f4f95147-83b6-47e8-9958-7bcb0029637d.jpg?v=1707509974","url":"https:\/\/danabiosci.com\/products\/new-product-232913","provider":"Dana Bioscience","version":"1.0","type":"link"}