{"product_id":"new-product-232892","title":"CD3G polyclonal antibody","description":"\u003cp\u003eThe T cell antigen receptor (TCR) recognizesforeign antigens and translates such recognition eventsinto intracellularsignalsthat elicit a change in the cell froma dormant to an activated state.Much of this signaling processcan be attributed to a multisubunitcomplex of proteins that associates directly with the TCR. Thiscomplex has been designated CD3 (cluster of differentiation 3). It iscomposed of five invariant polypeptide chainsthat associate to form three dimers: a heterodimer of γ and ε chains(γε), a heterodimer of δ and ε chains(δε) and a homodimer of two ζ chains(ζζ) or a heterodimer of ζ and η chains(ζη). The ζ and η chains are encoded bythe same gene but differ in theircarboxyl-terminal ends due to an alternative splicing event. The γ, ε and δ chains each contain a single copy of a conserved immunoreceptor tyrosine-based activationmotif (ITAM). In contrast, the ζ chain containsthree consecutive copies of the same motif. Phosphorylated ITAMs act as docking sitesfor protein kinases such as ZAP-70 and Syk and are also capable of regulating theirkinase activity. The crystalstructure of ZAP-70’s SH2 domains bound to the ζ chain ITAMs has been solved.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47664092971288,"sku":"BS60356","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_21ec14aa-4914-496a-9223-1ff1093edcdd.jpg?v=1707509890","url":"https:\/\/danabiosci.com\/products\/new-product-232892","provider":"Dana Bioscience","version":"1.0","type":"link"}