{"product_id":"new-product-232732","title":"AICDA polyclonal antibody","description":"\u003cp\u003eActivation-induced Cytidine Deaminase (AID, HIGM-2) is a 198-amino acid, RNA-editing enzyme that contains a conserved cytidine deaminase motif and plays an important role in B-cell terminal differentiation. AID is expressed in germinal center B cells and contributes to the production of neutralizing antibodies IgG, IgA, and IgE. Hyper-IgM syndrome (HIGM2) patients that have deficient levels of AID show the absence of immuno-globulin class switch recombination (CSR), lack of immuno-globulin somatic hypermutations, and lymph node hyperplasia mediated by the presence of giant germinal centers. Furthermore, AID-\/- mice are defective in CSR and also show a hyper-IgM phenotype, characterized by enlarged germinal centers containing active B cells. AID thus appears to be required in several stages of B-cell terminal differentiation that are necessary for efficient antibody responses such as B cell proliferation, immunoglobulin somatic hypermutations and CSR.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Rat","offer_id":47664035496216,"sku":"BS60554","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_7abd8a34-affa-499e-8fa8-c3d3a83b1972.jpg?v=1707509236","url":"https:\/\/danabiosci.com\/products\/new-product-232732","provider":"Dana Bioscience","version":"1.0","type":"link"}