{"product_id":"new-product-232683","title":"CX3CL1 polyclonal antibody","description":"\u003cp\u003eChemokines are members of a superfamily of inducible, secreted, proinflammatory cytokines. Members of the chemokine family exhibit 20-50%\u003cbr\u003e\nhomology in their predicted amino acid sequences and are divided into four\u003cbr\u003e\nsubfamilies. In the subfamily designated C-C or β, the first two cysteines are\u003cbr\u003e\nadjacent. In the C-X-C or a subfamily, the first two of four cysteine residues\u003cbr\u003e\nare separated by a single amino acid. C subfamily members, also designated\u003cbr\u003e\nγ chemokines, lack the first and third cysteine residues of the conserved\u003cbr\u003e\nmotif. Chemokines in these three subfamilies are small, secreted proteins\u003cbr\u003e\nwith molecular weights ranging from 7-15 kDa. Fractalkine, also designated\u003cbr\u003e\nneurotactin, is the first characterized member of a fourth chemokine subfamily.\u003cbr\u003e\nFractalkine contains a novel C-X3-C motif in which the first two cysteines\u003cbr\u003e\nare separated by three amino acid residues. Fractalkine mRNA has been\u003cbr\u003e\ndetected in brain and heart and is upregulated in microglia and endothelial\u003cbr\u003e\ncells by inflammatory signals. The protein can exist both as a membranebound\u003cbr\u003e\nform and as a chemotactic soluble form.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47664017309976,"sku":"BS60619","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_0cdcba6d-8864-4f98-9653-0fe25af20e47.jpg?v=1707508987","url":"https:\/\/danabiosci.com\/products\/new-product-232683","provider":"Dana Bioscience","version":"1.0","type":"link"}