{"product_id":"new-product-232679","title":"IL3RA polyclonal antibody","description":"\u003cp\u003eIL3RA\/CD123 is the alpha subunit of an IL-3 receptor that also contains the common beta chain (βc) shared with receptors for other cytokines. IL3RA\/CD123 alone binds to IL-3 with high specificity but low affinity and it does not transduce intracellular signaling, while βc alone does not bind to IL-3 appreciably. Together, IL3RA\/CD123 and βc form the functional high-affinity receptor for IL-3. IL3RA\/CD123 is mainly expressed on the hematopoietic progenitor cells, primarily the granulocytic and monocytic linages . IL3RA\/CD123 is highly expressed on leukemic stem cells in the majority of AML (acute myeloid leukemia) patients and is correlated with poor prognosis. In addition, overexpression of IL3RA\/CD123 has also been reported for other hematopoietic malignancies . It is considered as a valuable therapeutic target for these malignancies .\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"l\/1ml \/ Rabbit \/ Human,Rat","offer_id":47664016163096,"sku":"BS60620-B","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_4c055710-c519-491f-8af7-3ab8b0b270bb.jpg?v=1707508964","url":"https:\/\/danabiosci.com\/products\/new-product-232679","provider":"Dana Bioscience","version":"1.0","type":"link"}