{"product_id":"new-product-232605","title":"ITIH3 polyclonal antibody","description":"\u003cp\u003eThe inter-α trypsin inhibitor (ITI) family is a group of structurally related\u003cbr\u003e\nplasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-H1, ITI-H2 and ITI-H3) and one light chain (Bikunin). A fourth member of the ITI family, ITI-H4 (also known as I α IH4P) harbors a Pro-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins),bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. Although ITI-H1, ITI-H3 and Bikunin have antitumoral and antimetastatic properties in the cell, these proteins are also associated with malignant transformation of lung tissue. ITI-H3 and Bikunin associate to form pre-α-trypsin inhibitor (PαI), a serine-proteinase inhibitor found in human serum.ITI-H3 mRNA levels increase in response to IL-6.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":47663977201944,"sku":"BS60741","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_8e72b977-9e2e-4839-8f34-7b1d0278b05b.jpg?v=1707508627","url":"https:\/\/danabiosci.com\/products\/new-product-232605","provider":"Dana Bioscience","version":"1.0","type":"link"}