{"product_id":"new-product-232578","title":"CYFIP1 polyclonal antibody","description":"\u003cp\u003eFragile X syndrome is the most frequent form of inherited mental retardation and is a result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 protein (also designated FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. FMR1 can also interact with two fragile X syndrome related factors, FXR1 (also designated FXR1P) and FXR2 (also designated FXR2P). These proteins form heterodimers through their N-terminal coiled-coiled domains. CYFIP1 and CYFIP2 (also known as cytoplasmic FMRP interacting proteins 1 and 2, respectively, and as Sra-1 in mouse) both interact with FMR1 but CYFIP2 also reacts with FXR1 and FXR2. CYFIP1 and CYFIP2 bind GTP-bound Rac1 to release FMRP in its active state, which is thought to regulate mRNA translation of neural cytoskeletal proteins. A loss of CYFIP1 and CYFIP2 leads to mutant neurons with defective axonal growth and motor function.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47663967371544,"sku":"BS60773","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_074a8adb-c193-44da-8fed-1e6f07eb8101.jpg?v=1707508500","url":"https:\/\/danabiosci.com\/products\/new-product-232578","provider":"Dana Bioscience","version":"1.0","type":"link"}