{"product_id":"new-product-232552","title":"TBC1D2 polyclonal antibody","description":"\u003cp\u003eGTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. TBC1D2 (TBC1 domain family member 2), also known as Armus or PARIS-1 (prostate antigen recognized and identified by SEREX 1), is a 928 amino acid protein containing a Rab-GAP TBC domain and a PH domain. Localizing to cytoplasm, cytoplasmic vesicles and cell junctions, TBC1D2 is expressed in a broad range of tissues, including kidney, liver, lung and placenta, as well as in keratinocytes and epithelia-containing organs. TBC1D2 functions as a GTPase-activating protein for RAB7, and also acts as a linker between RAB7 and RAC1, which leads to RAB7A inactivation and inhibition of E-cadherin degradation. Existing as six alternatively spliced isoforms, the gene encoding TBC1D2 maps to human chromosome 9q22.33.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47663957377304,"sku":"BS60814","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_3a27e5bc-2d72-474e-b0b3-ccc24626d4f8.jpg?v=1707508382","url":"https:\/\/danabiosci.com\/products\/new-product-232552","provider":"Dana Bioscience","version":"1.0","type":"link"}