{"product_id":"new-product-232510","title":"VIPR1 polyclonal antibody","description":"\u003cp\u003eThe vasoactive intestinal peptide (VIP) and pituitary adenylate cylase-activating polypeptide (PACAP) belong to a superfamily of peptide hormones that include glucagon, secretin and growth hormone releasing hormone (1,2). The effects of VIP and PACAP are mediated by three G-protein coupled receptors, VPAC1, VPAC2 and the PACAP receptor (also designated PAC1-R) (1,2). The VPAC receptors have equal affinities for VIP and PACAP, which stimulate the activation of adenylyl cyclase (1,3). Both VPAC1 and VPAC2 are abundantly expressed in brain and T cells, where they modulate neuronal differentiation and T cell activation, respectively (1,4-6). The PACAP receptor is a seven transmembrane protein that produces at least eight isoforms by alternative splicing (2). Each isoform is associated with a specific signaling pathway and a specific expression pattern (2). The PACAP receptor, which is thought to play an integral role in brain development, preferentially binds PACAP in order to stimulate a cAMP-protein kinase A signaling pathway (2,7).\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47663932703000,"sku":"BS60880","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_226fd95f-3e3a-48cb-b48e-b3b7eb9f72ae.jpg?v=1707508168","url":"https:\/\/danabiosci.com\/products\/new-product-232510","provider":"Dana Bioscience","version":"1.0","type":"link"}