{"product_id":"new-product-232409","title":"CCP110 polyclonal antibody","description":"\u003cp\u003eCentrosome duplication and separation are linked inextricably to certain cell cycle events, specifically, activation of cyclin-dependent kinases of cyclin-dependent kinases. CP110 (centrosomal protein of 110 kDa) is a 991 amino acid cell cycle-dependent CDK substrate that regulates centrosome duplication. Localizing to the centrosome, CP110 contains ten putative CDK2 phosphorylation sites, two cyclin-binding domains and two degradation motifs. CP110 is highly expressed in testis with much lower expression in all other tissues. CP110 interacts with Ca2+-binding proteins including calmodulin (CaM) and centrin, to regulate genome stability and progression through cytokinesis. During the formation of cylindrical centrioles, it is suggested that CP110 acts as a distal end-capping protein thereby limiting the elongation of newly formed centrioles. Existing as two alternatively spliced isoforms, CP110 is observed at highest levels during the S phase of the cell cycle. CP110 becomes phosphorylated by Cdks (cyclin-dependent kinases) and is encoded by a gene located on human chromosome 16p12.3.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":47663853338904,"sku":"BS61151","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_2d2f11f0-f0ae-49c2-a6f3-76fe014d958c.jpg?v=1707507687","url":"https:\/\/danabiosci.com\/products\/new-product-232409","provider":"Dana Bioscience","version":"1.0","type":"link"}