{"product_id":"new-product-232332","title":"IL13RA2 polyclonal antibody","description":"\u003cp\u003eThe Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR). Two different receptors exist for IL-13, designated IL-13Rα1 and 2. IL-13Rα1 exists as a heterodimer of IL-13Rα1 and IL-4Rα as a signaling subunit, whereas IL-13Rα2 acts as a decoy receptor for IL-13. Furthermore, TNFα or IL-4 stimulation induces IL-13Rα2 upregulation, while IL-13Rα1 is constitutively expressed. Cell surface localization of IL-13Rα2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13Rα1 expression is predominant in B cells, monocytes and T cells, whereas IL-13Rα2 expression is highest in glioma cells.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47663747203352,"sku":"BS61342","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_77dabfd3-1782-4420-95ff-dfe9b25be19d.jpg?v=1707507316","url":"https:\/\/danabiosci.com\/products\/new-product-232332","provider":"Dana Bioscience","version":"1.0","type":"link"}