{"product_id":"new-product-232237","title":"DUSP16 polyclonal antibody","description":"\u003cp\u003eDUSP16\/MKP7 is a negative regulator of the JNK\/SAPK family of stress-activated MAP kinases. It inhibits JNK-mediated signaling events by dephosphorylating threonine and tyrosine residues within the activation loop of JNK proteins, effectively preventing further activation of downstream effectors. DUSP16\/MKP7 expression has been shown to be upregulated after oxidative stress, presumably as a means of supressing JNK activity in order to return the cells to a homeostatic state. DUSP16 is normally turned over at a high-rate in most cells, but the stability of the protein can be enhanced by Erk1\/2-mediated phosphorylation on Ser446, indicating that activation of mitogenic signaling pathways can supress stress-response pathways via stabilization of a JNK phosphatase . Despite demonstrating a substrate preference towards JNK proteins, DUSP16\/MKP7 has been shown to interact with other MAPK family members (Erk1\/2, p38 MAPKs) as well as scaffolding proteins that may coordinate its activity and specificity.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47663633989912,"sku":"BS61547","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_269d3fdc-d8f3-4a7e-97af-ecc57925e189.jpg?v=1707506836","url":"https:\/\/danabiosci.com\/products\/new-product-232237","provider":"Dana Bioscience","version":"1.0","type":"link"}