{"product_id":"new-product-232227","title":"BAG5 polyclonal antibody","description":"\u003cp\u003eBag-5 (Bcl-2-associated athanogene 5),also known as Bag family molecular chaperone regulator 5,is a member of the Bag family of proteins and contains four Bag domains.Via their Bag domain, Bag proteins bind with high affinity to the HSC 70\/HSP 70 ATPase domain, regulating chaperone activity and apoptosis.Bag-5 is a component of the HSP 70\/Parkin complex and acts to inhibit Parkin E3 ubiquitin ligase activity and HSP 70 chaperone activity. In this complex, Bag-5 directly interacts with the ATPase domain of HSP 70 and the N-terminal linker region of Parkin. Bag-5 expression is induced upon dopaminergic neuron injury and functions to sensitize the neurons to injuryinduced cell death. In addition, Bag-5 may be a useful target in therapies for neurodegenerative diseases such as Parkinson’s disease which is caused by a mutation in the gene encoding Parkin.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47663628222744,"sku":"BS61560","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_235a6554-c9c1-468f-bde7-b061ff0c617d.jpg?v=1707506808","url":"https:\/\/danabiosci.com\/products\/new-product-232227","provider":"Dana Bioscience","version":"1.0","type":"link"}