{"product_id":"new-product-232219","title":"PRPF19 polyclonal antibody","description":"\u003cp\u003eThe spliceosome, the gigantic molecular machine that performs pre-mRNA\u003cbr\u003e\nsplicing in eukaryotes, contains over 200 different proteins and 5 RNA\u003cbr\u003e\nmolecules (U1, U2, U4, U5 and U6). Pre-mRNA splicing is essential to remove\u003cbr\u003e\ninternal non-coding regions of pre-mRNA (introns) and to join the remaining\u003cbr\u003e\nsegments (exons) into mRNA before translation. The PRP19-associated complex\u003cbr\u003e\nis required for stable association of U5 and U6 with the spliceosome\u003cbr\u003e\nafter U4 is released. Changes within the spliceosome upon binding of the\u003cbr\u003e\nPRP19-associated complex include remodeling of the U6\/5' splice site interaction\u003cbr\u003e\nand destabilization of Lsm proteins to allow further interaction of U6\u003cbr\u003e\nwith the intron sequence.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47663609020696,"sku":"BS61565","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_2571990b-7004-4f0d-bfe4-00b1ccf2b781.jpg?v=1707506782","url":"https:\/\/danabiosci.com\/products\/new-product-232219","provider":"Dana Bioscience","version":"1.0","type":"link"}