LDLRAD1 polyclonal antibody

Low-density lipoprotein receptor class A domain-containing protein 1, belonging to the Low-density lipoprotein receptor class A domain-containing protein family.LDLRAD1 and LDLRAD2 function as recetor, LDLRAD3 may influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production,LDLRAD3 functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.