{"product_id":"new-product-232001","title":"Smad4 polyclonal antibody","description":"\u003cp\u003eMembers of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmits TGF-尾 signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the recepter-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7. Briefly, activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved SSXS motif at the carboxy-terminus of the proteins. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad, Smad4, and together the complex moves to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47663316566296,"sku":"BS61802","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_7f0e8be7-b781-41de-8be4-06101063a69c.jpg?v=1707505752","url":"https:\/\/danabiosci.com\/products\/new-product-232001","provider":"Dana Bioscience","version":"1.0","type":"link"}