{"product_id":"new-product-231920","title":"DSCR1 polyclonal antibody","description":"\u003cp\u003eCalcipressin-1, also known as DSCR1 (Down syndrome critical region 1), Adapt78, MCIP1 (myocyte-enriched calcineurin-interacting protein 1) or regulator of calcineurin 1, is a 252 amino acid protein that belongs to the RCAN family and exists as four alternatively spliced isoforms. Abundantly expressed in skeletal muscle, brain and heart, DSCR 1 is thought to influence cardiac and nervous system development. Overexpression of DSCR1 may play a role in the pathogenesis of Down syndrome. DSCR1 interacts with Raf-1 and has been observed to inhibit calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. The gene encoding DSCR 1 maps to human chromosome 21, which which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21).\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47663237431576,"sku":"BS62261","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_9542a158-1611-4145-83cd-ba43324232e8.jpg?v=1707505331","url":"https:\/\/danabiosci.com\/products\/new-product-231920","provider":"Dana Bioscience","version":"1.0","type":"link"}