{"product_id":"new-product-231305","title":"USP44 polyclonal antibody","description":"\u003cp\u003eDeubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex\/cyclosome (APC\/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC\/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC\/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":47663023554840,"sku":"BS67086","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_39727d9f-15a2-4924-be35-4c584bbe7083.jpg?v=1707502444","url":"https:\/\/danabiosci.com\/products\/new-product-231305","provider":"Dana Bioscience","version":"1.0","type":"link"}