{"product_id":"new-product-231183","title":"IL-17RA polyclonal antibody","description":"\u003cp\u003eReceptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539).\u003cbr\u003e\nReceptor for IL17F (PubMed:19838198, PubMed:17911633).\u003cbr\u003e\nBinds to IL17A with higher affinity than to IL17F (PubMed:17911633).\u003cbr\u003e\nBinds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495).\u003cbr\u003e\nAlso binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971).\u003cbr\u003e\nCytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:24120361, PubMed:17911633, PubMed:18684971, PubMed:21350122).\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Rat,Mouse","offer_id":47663003173144,"sku":"BS67226","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_d34def81-9199-417e-92d9-84b8e90a502d.jpg?v=1707501850","url":"https:\/\/danabiosci.com\/products\/new-product-231183","provider":"Dana Bioscience","version":"1.0","type":"link"}