{"product_id":"new-product-231063","title":"BCKDHA polyclonal antibody","description":"\u003cp\u003eBranched-chain amino acids (BCAAs) leucine, isoleucine, and valine are essential amino acids in mammals, but elevated levels of BCAAs have been implicated in cardiovascular and metabolic disorders. The branched-chain α-keto acid dehydrogenase complex (BCKDH) catalyzes the rate-limiting step in the BCAA degradation pathway. Branched-chain α-keto acid decarboxylase (BCKDH-E1) is one of three enzymatic components in this complex. The α subunit of BCKDH-E1 (BCKDH-E1α) is critical for the regulation of BCKDH. Phosphorylation of BCKDH-E1α was shown to play a key role in regulating the enzymatic activity of this complex.\u003cbr\u003e\nPhosphorylation of BCKDH-E1α at Ser293 inactivates BCKDH. A significant elevation in plasma BCAA levels was reported to correlate with increased phosphorylation of BCKDH-E1α at Ser293 and suppressed BCKDH activity in the liver of diabetic mice.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human, Mouse, Rat","offer_id":47662982562072,"sku":"BS67347","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_e48976c0-6069-486c-ad90-b7d1fa660869.jpg?v=1707501226","url":"https:\/\/danabiosci.com\/products\/new-product-231063","provider":"Dana Bioscience","version":"1.0","type":"link"}