{"product_id":"new-product-230987","title":"PLSCR1 polyclonal antibody","description":"\u003cp\u003ePhospholipid scramblase 1 (PLSCR1) is 1 of 4 scramblases encoded in the human genome. Phospholipid scramblases function to catalyze calcium-mediated ATP-independent mobilization of phospholipids between the inner and outer leaflet of plasma membrane in activated, injured, or apoptotic cells. PLSCR1 is a type-II transmembrane protein with a short 9 amino acid C-terminal domain and a long N-terminal extracellular domain. Although PLSCR1 is part of a family of proteins that function to catalyze phospholipid mobilization, PLSCR1 may have alternative functions. Rather, PLSCR1 may function to activate cell signaling pathways, particularly in phagocytic cells of monocyte\/macrophage lineage. Microglia, resident macrophages of the brain, play a key role in clearance of cellular and pathologic debris where altered phagocytosis may contribute to neurodegenerative diseases like Alzheimer’s disease. PLSCR1 may regulate microglia phagocytosis, representing a potential therapeutic target to modulate microglia phagocytosis.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Rat,Mouse","offer_id":47662973026584,"sku":"BS8540","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_1183301b-ba4e-451f-a551-c6248791ca0c.jpg?v=1707500881","url":"https:\/\/danabiosci.com\/products\/new-product-230987","provider":"Dana Bioscience","version":"1.0","type":"link"}