{"product_id":"new-product-230950","title":"GADD 45γ (S123) polyclonal antibody","description":"\u003cp\u003eCell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Thus, it has been suggested that GADD 45 may serve as a link between the p53-dependent cell cycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45β and GADD 45γ, have been shown to be induced by environmental stresses. GADD 45β and GADD 45γ are thought to induce p38\/JNK activation via MEKK4 activation.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47662969520408,"sku":"BS9140","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_da666809-a09b-4166-8fb8-7247a5a690d2.jpg?v=1707500733","url":"https:\/\/danabiosci.com\/products\/new-product-230950","provider":"Dana Bioscience","version":"1.0","type":"link"}