{"product_id":"new-product-230817","title":"SF1 polyclonal antibody","description":"\u003cp\u003eMammalian splicing factor 1 (designated SF1, zinc finger protein 162, ZFM1,CW17R and mammalian branch point binding protein [mBBP]) specificallyrecognizes the seven-nucleotide branch point sequence located at 3' splicesites and participates in the assembly of early spliceosomal complexes.Splicing factor 1 functions as a transcriptional repressor and may control bothproliferation and expression of pro-inflammatory gene products in smoothmuscle cells. In addition, cytokine-induced downregulation of splicing factor 1 expression may contribute to the pathogenesis of hyperproliferative inflammatory diseases. The structure of splicing factor 1 contains a nuclear transport domain, a metal binding motif, and glutamine- and proline-rich regions.Human splicing factor 1 also exists as several different isoforms, H1-isoformand Bo-isoform, produced by alternative splicing events. The human splicingfactor 1 gene is located on chromosome 11 close to the gene encoding Menin,the gene responsible for multiple endocrine neoplasia-type 1 (MEN1).\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":47662942912792,"sku":"GCP58","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_604894ff-3dbd-42f2-85f4-5fcf61028d04.jpg?v=1707500132","url":"https:\/\/danabiosci.com\/products\/new-product-230817","provider":"Dana Bioscience","version":"1.0","type":"link"}