{"product_id":"new-product-230717","title":"IL-17A monoclonal antibody","description":"\u003cp\u003eIL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th17 cells, a distinct CD4+ T cell lineage. IL-17A stimulates the production of the pro-inflammatory cytokines IL-1β, TNF-α, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity. IL-17A is intimately involved in mucosal immunity against bacterial infections and has a putative role in some autoimmune disorders. IL-17A effects appear to be exerted primarily through binding to the IL-17RA. IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the Erk1\/2 MAP kinase, PI3K\/Akt, p38, and NF-κB pathways. Phosphorylation of some Jaks and Stats has been observed.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Mouse \/ Human","offer_id":47662917681432,"sku":"MB65815","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_d0e56de1-f010-4282-8bb8-2895e34baee8.jpg?v=1707499667","url":"https:\/\/danabiosci.com\/products\/new-product-230717","provider":"Dana Bioscience","version":"1.0","type":"link"}