{"product_id":"new-product-230704","title":"CD8a Rat monoclonal antibody","description":"\u003cp\u003eCluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rat \/ Mouse","offer_id":47662916567320,"sku":"MB65828","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_58b8d784-5e1d-4f80-9559-c090f53e9b7f.jpg?v=1707499601","url":"https:\/\/danabiosci.com\/products\/new-product-230704","provider":"Dana Bioscience","version":"1.0","type":"link"}