{"product_id":"new-product-230687","title":"CD223 Rat monoclonal antibody","description":"\u003cp\u003eLymphocyte activation gene 3 (LAG-3, CD223) is an immune checkpoint control protein that negatively regulates T cells and immune responses. A CD4-like member of the Ig superfamily, LAG3 contains an extracellular IgV and three IgC domains, a transmembrane domain, and a short cytoplasmic region. LAG3 is primarily expressed by activated CD4+ T cells, CD8+ T cells, Tregs, and NK cells, where it's activated by MHC Class II molecules, its only known ligand. While it was initially shown to activate Treg cells, LAG3 can also inhibit CD8+ T cells. LAG3 is often co-expressed with PD-1 on the surface of tumor infiltrating lymphocytes, where the two proteins act independently to contribute to tumor-mediated immune suppression. Blockade of LAG3 is a promising strategy for neoplastic intervention.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rat \/ Mouse","offer_id":47662912635160,"sku":"MB65845","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_e7317ac5-dbfe-4401-9c05-4851589a14a3.jpg?v=1707499514","url":"https:\/\/danabiosci.com\/products\/new-product-230687","provider":"Dana Bioscience","version":"1.0","type":"link"}