{"product_id":"new-product-230657","title":"BCL2 monoclonal antibody","description":"\u003cp\u003eBcl-2 exerts a survival function in response to a wide range of apoptotic stimuli through inhibition of mitochondrial cytochrome c release. It has been implicated in modulating mitochondrial calcium homeostasis and proton flux. Several phosphorylation sites have been identified within Bcl-2 including Thr56, Ser70, Thr74, and Ser87. It has been suggested that these phosphorylation sites may be targets of the ASK1\/MKK7\/JNK1 pathway and that phosphorylation of Bcl-2 may be a marker for mitotic events. Mutation of Bcl-2 at Thr56 or Ser87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes. Interleukin-3 and JNK-induced Bcl-2 phosphorylation at Ser70 may be required for its enhanced anti-apoptotic functions.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Mouse \/ Human, Mouse, Rat","offer_id":47662909620504,"sku":"MB65877","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_454ffb6a-b4ef-4654-98ed-61805c713df6.jpg?v=1707499396","url":"https:\/\/danabiosci.com\/products\/new-product-230657","provider":"Dana Bioscience","version":"1.0","type":"link"}