{"product_id":"new-product-230448","title":"MUC6 monoclonal antibody","description":"\u003cp\u003eMucin 6 (also designated MUC 6 and gastric mucin) is a large glycoprotein that plays a major role in the protection of the gastrointestinal tract. Mucin 6 carries GlcNAca1Æ4GalβÆR structures, indicating that a1,4-N-acetylglucosaminyltransferase is important to the formation of the mucous glycoproteins in vivo. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 apomucin is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation. Mucin 6 mRNA is expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development, and Mucin 6 glycoprotein is expressed in the epithelium of ureteric buds and collecting ducts, but absent from adult kidney. Proliferating bile ductular cells express Mucin 6 apomucin in diseased liver, especially in chronic viral hepatitis with active necroinflammation, suggesting that this secreted mucin acts as a cytoprotective agent and represents a phenotype of reactive biliary epithelium in chronic viral hepatitis.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Mouse \/ Human","offer_id":47662882128152,"sku":"MB66085","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_9535c0cf-0027-48f3-b57d-89429e7f6db8.jpg?v=1707498463","url":"https:\/\/danabiosci.com\/products\/new-product-230448","provider":"Dana Bioscience","version":"1.0","type":"link"}