{"product_id":"new-product-230399","title":"IGF2 monoclonal antibody","description":"\u003cp\u003ensulin-like growth factor 2 (IGF-II, IGF-2) is a peptide growth factor with structural similarity to insulin and insulin-like growth factor 1 (IGF-I). IGF-II is reported to interact with multiple cell-surface receptors, including type 1 insulin-like growth factor receptor (IGF1R), insulin receptor A isoform (IR-A), and the structurally distinct type-2 IGF receptor (IGF2R) . Activation of IGF1R and IR-A by IGF-II promotes cell growth, proliferation, apoptosis, and metabolic signaling ; binding of IGF-II to IGF2R (a.k.a. mannose 6-phosphate receptor) results in IGF-II internalization via receptor-mediated endocytosis, and subsequent transport to the lysosome for degradation . Serum IGF-II is generally found in complex with insulin-like growth factor binding proteins (IGFBPs), to which it binds with high affinity; this interaction functions to prolong the half-life of IGF-II in circulation . IGF-II plays a particularly crucial role in promoting embryonic fetal growth and development ; in rodents, many of these functions are displaced by IGF-I during normal postnatal development, whereas in humans, IGF-II expression is more widely maintained . Binding of IGF-II to both IGF1R and IR-A has been shown to promote cancer progression, primarily through promoting cell proliferation and survival . Small molecules designed to block IGF-II activity are thus being pursued as therapeutic strategies for cancer treatment .\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Mouse \/ Human","offer_id":47662875377944,"sku":"MB66134","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_ac6eaa56-cfed-44e8-85f3-b07fc47b28c1.jpg?v=1707498201","url":"https:\/\/danabiosci.com\/products\/new-product-230399","provider":"Dana Bioscience","version":"1.0","type":"link"}