{"product_id":"new-product-230369","title":"MUC2 monoclonal antibody","description":"\u003cp\u003eMucins are a family of large glycoproteins that create the structural component of mucus. Mucus functions as a blockade against pathogenic invasion and physical injury to the respiratory, gastrointestinal, and urogenital tracts . Mucins create a protective layer for epithelial cells as either membrane-bound (MUC1, MUC3, MUC16, and MUC17) or secreted (MUC2, MUC5AC, and MUC19) proteins. MUC2, or mucin-2, the main O-glycosylated protein found in mucus, is secreted by goblet cells. The structure of MUC2 contains cysteine-rich N- and C-terminal domains along with a protein core made up of heavily O-glycosylated mucin domains. The high levels of O-glycosylation along with disulfide bonding make MUC2 resistant to proteolytic cleavage . Mucin expression and glycan structure changes occur in cancers of the intestine and impact the development and progression of these cancers . The presence of MUC2 in the mucous layer of the colon helps prevent ulcerative colitis (UC) by inhibiting the invasion of bacteria .\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Mouse \/ Human","offer_id":47662871445784,"sku":"MB66163","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_c8817553-0598-404e-8230-837a9be4206a.jpg?v=1707498062","url":"https:\/\/danabiosci.com\/products\/new-product-230369","provider":"Dana Bioscience","version":"1.0","type":"link"}