{"product_id":"new-product-230296","title":"Perforin 1 monoclonal antibody","description":"\u003cp\u003eGranzymes are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer (NK) cells and are key components of immune responses to pathogens and transformed cells . Granzymes are synthesized as zymogens and are processed into mature enzymes by cleavage of a leader sequence. They are released by exocytosis in lysosome-like granules containing perforin, a membrane pore-forming protein. Granzyme B has the strongest apoptotic activity of all the granzymes as a result of its caspase-like ability to cleave substrates at aspartic acid residues thereby activating procaspases directly and cleaving downstream caspase substrates (2,3).\u003cbr\u003e\nPerforin is a pore-forming protein that facilitates the entry of cytotoxic serine proteases, such as granzymes, into target cells . Perforin is primarily expressed in cytotoxic T lymphocytes and NK cells.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Mouse \/ Human","offer_id":47662861091096,"sku":"MB66237","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_16af4a03-4f48-43b0-b140-e66bdbfe9079.jpg?v=1707497718","url":"https:\/\/danabiosci.com\/products\/new-product-230296","provider":"Dana Bioscience","version":"1.0","type":"link"}