{"product_id":"new-product-230212","title":"4E-BP1 (Phospho-Thr70) polyclonal antibody","description":"\u003cp\u003eTranslation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase\/Akt pathway and FRAP\/mTOR kinase regulate 4E-BP1 activity. Multiple 4E-BP1 residues are phosphorylated in vivo. While phosphorylation by FRAP\/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":47662739882264,"sku":"AP0155","price":348.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_b42be3e9-c80f-427d-b45d-729dd951abd4.jpg?v=1707493732","url":"https:\/\/danabiosci.com\/products\/new-product-230212","provider":"Dana Bioscience","version":"1.0","type":"link"}