{"product_id":"new-product-230191","title":"Tak1 (phospho-T184) polyclonal antibody","description":"\u003cp\u003eSeveral serine\/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK\/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a protein with intrinsic kinase activity towards serine\/threonine residues and that is widely expressed in many tissue types and cell lines. Raf-1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation occurs is poorly understood. Two proteins putatively involved in this process are Ksr-1 and Tak1. Ksr-1 (kinase suppressor of Ras) is a novel Raf-related protein kinase whose function is required for Ras signal transduction. Whether Ksr-1 lies directly downstream of Ras or acts in a parallel pathway is not yet known. Tak1 (TGFß-activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGFß stimulation.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47662737817880,"sku":"AP0342","price":348.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_54ac4478-740f-495c-96e6-17fe8e2cb5e1.jpg?v=1707493647","url":"https:\/\/danabiosci.com\/products\/new-product-230191","provider":"Dana Bioscience","version":"1.0","type":"link"}