{"product_id":"new-product-229738","title":"SLP-76 (phospho-Y128) polyclonal antibody","description":"\u003cp\u003eOverexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production. When co-expressed, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response. Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, serine\/threonine or lipid kinase families, it does contain several putative SH2\/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1. The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47662621688088,"sku":"BS4872","price":348.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_93cba338-f7b9-4333-b5c2-b24577104f2b.jpg?v=1707491225","url":"https:\/\/danabiosci.com\/products\/new-product-229738","provider":"Dana Bioscience","version":"1.0","type":"link"}