{"product_id":"new-product-229699","title":"Catenin-β (phospho-S33\/S37\/T41) polyclonal antibody","description":"\u003cp\u003eβ-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47662609989912,"sku":"BS5056","price":348.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_3a86fb49-6378-4bfe-92cb-e1e58da7064f.jpg?v=1707491061","url":"https:\/\/danabiosci.com\/products\/new-product-229699","provider":"Dana Bioscience","version":"1.0","type":"link"}