{"product_id":"new-product-229646","title":"14-3-3 θ\/YWHAQ (phospho-S232) polyclonal antibody","description":"\u003cp\u003eProtein interactions with 14-3-3 show distinct preferences for it’s different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 tau\/theta is primarily expressed in T-cells although it occurs at lower levels in the brain, heart, pancreas placenta and kidneys. It plays a role in cell cycle progression via interaction with p27(Kip1). Along with COPI, the theta isoform binds the GB1 RSR sequence involved in protein trafficking. The isoform forms a complex with Hsp60 and cellular prion protein which may be involved in prion diseases. Elevated levels of 14-3-3 tau\/theta are observed in amyotrophic lateral sclerosis. 14-3-3 tau\/theta also binds BCR\/Abl, bacterial effector protein Tir, yes-associated protein and the FSH receptor.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47662595080472,"sku":"BS64156","price":348.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_b37387a0-0a11-4fa8-afd0-9000d66f5c6f.jpg?v=1707490808","url":"https:\/\/danabiosci.com\/products\/new-product-229646","provider":"Dana Bioscience","version":"1.0","type":"link"}