{"product_id":"new-product-229584","title":"Cleaved-Notch 1 (V1754) polyclonal antibody","description":"\u003cp\u003eNotch1 is a transmembrane protein functioning in development and the determination of cell fate. During maturation, the notch molecule is cleaved by a furin-like convertase at its extracellular domain. Upon binding to a ligand such as Delta1, or upon extracellular calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1753 and Val1754. The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47662580302104,"sku":"BS7018","price":348.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_7e60e876-3e86-41e9-90f7-81f5e13c57e2.jpg?v=1707490544","url":"https:\/\/danabiosci.com\/products\/new-product-229584","provider":"Dana Bioscience","version":"1.0","type":"link"}