{"product_id":"new-product-229575","title":"CD4 (10H8) monoclonal antibody","description":"\u003cp\u003eCluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Mouse \/ Human,Mouse,Rat","offer_id":47662577713432,"sku":"MB8502","price":348.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_9da341a1-2c60-4f40-9d62-3256d0357119.jpg?v=1707490492","url":"https:\/\/danabiosci.com\/products\/new-product-229575","provider":"Dana Bioscience","version":"1.0","type":"link"}