{"product_id":"new-product-229318","title":"TNFAIP6 polyclonal antibody","description":"\u003cp\u003eThe TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNFα and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly\u003cbr\u003e\nin the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNFα, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-α-inhibitor (IαI)). TSG-6 potentiates the\u003cbr\u003e\ninhibitory effect of lαl on the protease activity of plasmin. Through their\u003cbr\u003e\ncooperative inhibitory effect on plasmin, TSG-6 and lαl can modulate the\u003cbr\u003e\nprotease network and thus inhibit inflammation.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47662497169688,"sku":"BS6310","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_bc3bdf33-88ba-47c9-b1ca-52a7aa70a09c.jpg?v=1707489241","url":"https:\/\/danabiosci.com\/products\/new-product-229318","provider":"Dana Bioscience","version":"1.0","type":"link"}