{"product_id":"new-product-229303","title":"TAL1 (Acetyl-K221\/K222) polyclonal antibody","description":"\u003cp\u003eActivation of TAL1 characterizes up to 60% ofcases of human T cell acute lymph oblastic leukemia,making it themost frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phospho protein and basic helixx-loop-helixtranscription factorknown to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB\/HTF4 to a nucleotide sequence motif termed the E-box.In addition, leukemogenesisis accelerated dramatically bytransgenic coexpression of TAL1 and the catalyticsubunit ofcasein kinase IIα, a serine\/threonine protein kinase known tomodulate the activity of other βHLH transcription factors.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47662487404824,"sku":"BS64094","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_aefa51ad-a09c-4d36-9862-939c132aa64f.jpg?v=1707489151","url":"https:\/\/danabiosci.com\/products\/new-product-229303","provider":"Dana Bioscience","version":"1.0","type":"link"}