{"product_id":"new-product-228615","title":"CREB3 polyclonal antibody","description":"\u003cp\u003eHCF-1 is a cellular protein required by VP16, a viral tegument, to activate the herpes simplex virus (HSV) immediate-early genes. In addition to playing an essential role in cell proliferation, HCF-1 also functions as a coactivator for the basic leucine zipper transcription factor LZIP (also designated Luman or CREB3 . Both LZIP and VP16 contain the binding motif (D\/E) HXY (S\/A), which is recognized by an amino terminal beta-propeller domain in HCF-1. LZIP, a member of the ATF\/CREB family, is a type II membrane-associated glycoprotein that is ubiquitously expressed in adult and fetal tissues. LZIP associates with the endoplasmic reticulum, where it sequesters most of the cellular HCF-1. Like other CREB\/ATF family members, LZIP activates transcription from genes containing cyclic AMP response elements (CREs) . LZIP activity is repressed by the inhibitory interaction of HCLP-1 .\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse","offer_id":47662382711064,"sku":"BS6947","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_a225772a-7841-4316-8c32-9d181b1ef626.jpg?v=1707485555","url":"https:\/\/danabiosci.com\/products\/new-product-228615","provider":"Dana Bioscience","version":"1.0","type":"link"}