{"product_id":"new-product-228244","title":"XRCC6 polyclonal antibody","description":"\u003cp\u003eThe Ku protein islocalized in the nucleus and iscomposed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86). Ku wasfirst described as an autoantigen to which antibodies were produced in a patient with scleroderma polymyositis overlap syndrome, and waslater found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cellsignaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription byvirtue of its DNA binding activity,serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. A Ku-related protein designated the enhancer binding factor (E1BF),composed of two subunits, has been identified as a positive regulator of RNA polymerase I transcription initiation.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat,Monkey","offer_id":47662325858584,"sku":"BS70792","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_fcacedad-49c5-46c5-aff4-494611f4adb3.jpg?v=1707483599","url":"https:\/\/danabiosci.com\/products\/new-product-228244","provider":"Dana Bioscience","version":"1.0","type":"link"}