{"product_id":"new-product-227392","title":"SHARPIN polyclonal antibody","description":"\u003cp\u003eComponent of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and\/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B\/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Rat","offer_id":47662185251096,"sku":"BS71652","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_82c8a6eb-d366-4de9-87ed-ccb5ffc0413d.jpg?v=1707479371","url":"https:\/\/danabiosci.com\/products\/new-product-227392","provider":"Dana Bioscience","version":"1.0","type":"link"}