{"product_id":"new-product-226862","title":"GCN1L1 polyclonal antibody","description":"\u003cp\u003eActs as a positive activator of the EIF2AK4\/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4\/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4\/GCN2, and hence stimulating EIF2AK4\/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4\/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha\/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":47662106214680,"sku":"BS72185","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_9438d7cf-893b-46a7-9a01-4a6e435fdead.jpg?v=1707476842","url":"https:\/\/danabiosci.com\/products\/new-product-226862","provider":"Dana Bioscience","version":"1.0","type":"link"}