{"product_id":"new-product-226481","title":"GIT2 polyclonal antibody","description":"\u003cp\u003eHeterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. G protein-coupled receptor kinases(GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade. GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking. GIT1 overexpression results in reduced internalization and resensitization of β2-adrenergic receptor, thus reducing β2-adrenergic receptor signaling.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human","offer_id":47661992444184,"sku":"BS72578","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_e1fa084e-05f7-462d-91fb-135e2f2db0dd.jpg?v=1707474811","url":"https:\/\/danabiosci.com\/products\/new-product-226481","provider":"Dana Bioscience","version":"1.0","type":"link"}