{"product_id":"new-product-225926","title":"SETD8 polyclonal antibody","description":"\u003cp\u003eProtein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specificallymonomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tagfor epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role inthe silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance ofproper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis.Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53\/TP53 at 'Lys-382',leading to repress p53\/TP53-target genes.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661918093592,"sku":"BS7521","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_e82d4094-c9ac-4fbb-8675-62316c3a7958.jpg?v=1707471870","url":"https:\/\/danabiosci.com\/products\/new-product-225926","provider":"Dana Bioscience","version":"1.0","type":"link"}