{"product_id":"new-product-225790","title":"ABAT polyclonal antibody","description":"\u003cp\u003eIn the central nervous system GABA (γ-;aminobutyric acid) functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. ABAT (4-aminobutyrate aminotransferase), also known as GABAT (GABA aminotransferase), L-AIBAT or (S)-3-amino-2-methylpropionate transaminase, is a 500 amino acid mitochondrial matrix protein belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, which catabolizes GABA into succinic semialdehyde. Existing as a homodimer, ABAT binds pyridoxal phosphate as a cofactor and is expressed in liver, brain, pancreas, kidney, placenta and heart. The gene encoding ABAT maps to human chromosome 16p13.2, and defects in ABAT are the cause of GABA-AT deficiency, which is characterized by hypotonia, hyperreflexia, psychomotor retardation, lethargy, EEG abnormalities and refractory seizures.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661907411224,"sku":"BS7743","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_5ff62e15-e0c4-4cff-8b6c-8c6573eecbac.jpg?v=1707471118","url":"https:\/\/danabiosci.com\/products\/new-product-225790","provider":"Dana Bioscience","version":"1.0","type":"link"}