{"product_id":"new-product-225718","title":"CD319 polyclonal antibody","description":"\u003cp\u003eCS1, also known as novel Ly9, SLAMF7, CD319, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLCγ and PI 3-kinase. In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100ul \/ Rabbit \/ Human,Mouse,Rat","offer_id":47661903544600,"sku":"BS7859","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BIOWORLD_d2ccec99-7248-48b8-a010-59cec86c1430.jpg?v=1707470755","url":"https:\/\/danabiosci.com\/products\/new-product-225718","provider":"Dana Bioscience","version":"1.0","type":"link"}